Born in 1808 at Currie in Scotland, he was the eldest son of Alexander DENHOLM and Margaret CHRISTIE. He was left behind at Currie with his two brothers when their parents went to Van Diemen's land in 1822, but they followed on Wanstead in 1828.
George married Sarah BARNES in 1836 when he was probably working with his father at Currie Banks. He later leased large areas for grazing sheep.
They had ten children. He died at Bothwell in 1884.